마우스의 아세트알데히드 대사에 미치는 인삼 부탄올 분획의 영향

• 영문명: The Effect of Ginseng Butanol Fraction on the Acetaldehyde Metabolism in Mice
• 발행기관: 대한약학회
• 저자명: 허근(Keun Huh) 박종민(Chong Min Park) 이상일(Sang Il Lee) 최종원(Chong Won Choi)
• 간행물 정보: 『약학회지』제29권 제1호 (1985년), 18~26쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1985.02.28

영문 초록

The present study was undertaken to investigate the possible effect of ginseng butanol fraction on the hepatic acetaldehyde metabolism. Experimental animals were used for the subject of the study. When, in case of mitochondrial aldehyde dehydrogenase (Ald DH), ginseng butanol fraction was added, enzyme activity was increased in a small dose, while, in a large dose, it showed inhibitory effect. In terms of kinetic aspect, ginseng butanol fraction has the effect to decrease the Km values of Ald DH, In vivo studies, the activity of Ald DH increased by induction of acute intoxication of ethanol was further increased through pretreatment with ginseng butanol fraction. When ginseng butanol fraction was given to mice fed with 5% ethanol instead of water for 60 days, the activity of Ald DH in mitochondrial fraction decreased to about 35% in chronic alcoholism, but after pretreatment of ginseng butanol fraction the activity was restored to the control level. By the pretreatment with disulfiram, the Ald DH activity was inhibited in normal and alcohol-treated groups, but after the treatment with ginseng butanol fraction the activity was restored to the control level. The results suggest that ginseng butanol fraction enhance the Ald DH activity inhibited by the treatment of disulfiram with no relation to NAD. It was observed that ginseng butanol fraction markedly decrease the acetaldehyde levels in plasma and liver. All these observations suggested that reduction of acetaldehyde in blood and liver should be dependent upon increased activity of mitochondrial Ald DH. It is concluded that the recovery from alcohol intoxication should be prompted by treatment with ginseng.