흡광광도법 및 원자흡광광도법에 의한 Pipethanate.HCl의 정량

• 영문명: Determination of Pipethanate.HCl by Spectrophotometry and Atomic Absorption Spectrophotometry
• 발행기관: 대한약학회
• 저자명: 이왕규(Wang Kyu Lee) 박만기(Man Ki Park) 김박광(Bak Kwang Kim) 손채연(Chae Yun Sohn)
• 간행물 정보: 『약학회지』제27권 제4호 (1983년), 303~307쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1983.12.30

영문 초록

Pipethanate.HCl reacts with ammonium cobaltothiocyanate to form a stable ion pair which has an absorption maximum at 626nm. The reaction product was insoluble in water but freely soluble in most organic solvents. 1, 2-Dichloroethane was the best extracting solvent among the several organic solvents. Pipethanate.HCl can be determined not only by the spectrophotometry but also indirectly by estimation of cobalt in the organic phase by atomic absorption spectrophotometry. Linear relationship was found between absorbance and concentration in the range of 1.0 X 10-3~4.0 X 10-3M by spectrophotometry and 1.5 X 10-4~4.O X 10-4M by atomic absorption spectrophotometry. With this method it was possible to determine pipethanate.HCl in the pharmaceutical preparations.