Piperine유도체의 합성 및 중추억제작용에 관한 연구(II) Piperic Acid Amide 유도체

• 영문명: Syntheses and Central Nervous Depressant Activities of Piperine Derivatives (II) Piperic Acid Amides
• 발행기관: 대한약학회
• 저자명: 은재순(Jae Soon Eun) 임중기(Joong Ki Rim) 김완주(Wan Joo Kim) 우원식(Won Sick Woo) 이은방(Eun Bang Lee)
• 간행물 정보: 『약학회지』제27권 제4호 (1983년), 283~287쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1983.12.30

영문 초록

In order to search more active and less toxic central nervous depressants, piperic acid amides were synthesized by condensation of piperonal with crotonic acid amides. The bioassay results revealed that, among the compounds synthesized, the piperonic acid methylamide and ethylamide exhibited potent protective activity against strychnine-induced convulsion.