약물과 생체고분자간의 상호작용(VI) Nalidixic Acid 및 Probenecid와 우혈청 단백간의 결합에 관한 연구

• 영문명: Drug-Biomacromolecule Interaction (VI) Binding of Nalidixic Acid and Probenecid to Bovine Serum Albumin
• 발행기관: 대한약학회
• 저자명: 김종국(Chong Kook Kim) 임연수(Yun Su Lim) 양지선(Ji Sun Yang)
• 간행물 정보: 『약학회지』제27권 제4호 (1983년), 257~261쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1983.12.30

영문 초록

Binding of nalidixic acid which is used primarily in the treatment of urinary infection and probenecid which is used as a uricosuric agent to bovine serum albumin were studied using difference spectrophotometric method. 2-(4''-Hydroxybenzeneazo) benzoic acid as a .spectrophotometric probe was used for measuring the binding of nalidixic acid and probenecid to bovine serum albumin. The association constants of nalidixic acid and probenecid were 1.58 X 104 M-1 and 1.70 X 104 M-1, respectively