Cholesterol, L-alpha-Phosphatidylinositol, L-alpha-Phosphatidylserine을 함유한 L-alpha-Dimyristoyl-phosphatidyl Choline 리포솜에 대한 Phospholipase D의 작용에 관한 연구

• 영문명: Effect of Phospholipase D on the L-alpha-Dimyristoyl-phosphatidyl Choline Liposome Containing Cholesterol, L-alpha-Phosphatidylinositol and L-alpha-Phosphatidylserine
• 발행기관: 대한약학회
• 저자명: 이은옥(Eun Ock Lee)
• 간행물 정보: 『약학회지』제27권 제4호 (1983년), 249~256쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1983.12.30

영문 초록

When the reaction rate constant k of phospholipase D on liposome was measured by the ANS fluorometry, k of phospholipase D on DMPC liposome which was made of L-alpha-PI, cholesterol and L-alpha-PS decreased than that of phospholipase D on DMPC liposome with cholesterol or with PI and cholesterol. Optimal Ca2+ concentration, the most important factor on effect of phospholipase D, also decreased to 1mM, as compared with 1OmM and 6OmM respectively when cholesterol and PI were added, and cholesterol only was added. The change of cholesterol Mol% had a great influence on k value of phospholipase D. But in case of addition of L-alpha-PS to cholesterol, the influence was relatively diminished.