중심 측두엽 극파 동반 양성 간질에서의 인지 행동 관찰 및 topiramate 1일 1회 투약효과

• 영문명: Cognitive and Behavioral Problems and the Effectiveness of Topiramate Once per Day in the Control of Benign Childhood Epilepsy with Centrotemporal Spikes
• 발행기관: 대한소아신경학회
• 저자명: 김윤미(Yun-Mi Kim) 김흥동(Heung Dong Kim) 이준수(Joon Soo Lee) 강훈철(Hoon-Chul Kang)
• 간행물 정보: 『Annals of Child Neurology(구 대한소아신경학회지)』대한소아신경학회지 제18권 제2호, 206~213쪽, 전체 8쪽
• 주제분류: 의약학 > 소아과학
• 파일형태: PDF
• 발행일자: 2010.11.30

영문 초록

Purpose : This study was aimed to evaluate cognitive and behavioral problems in benign childhood epilepsy with centrotemporal spikes (BECTS) using objective scales. In addition, we investigated the efficacy and cognitive effects of topiramate by intro- ducing it once a day as a pilot study. Methods : Seven patients were evaluated. They were diagnosed as BECTS based on clinical features and electroencephalography findings. We assessed cognitive and behavioral functions with several neuropsychological tests and followed up the sei- zure frequency, side effects, and cognitive dysfunction for six months after intro- ducing topiramate once per day. Results : The mean intelligence quotient, memory quotient, and social quotient of patients show the difference as compared to the general population. However, three patients showed attention deficit/hyperactivity disorder. Further, the seizure reduc- tion rate was 100% after receiving topiramate once a day and there were no newly reported neuropsychological problems on questionnaires. Conclusion : This study demonstrated that a significant number of children with BECTS have behavioral problems and that topiramate monotherapy once a day is effective.

목차

서 론

대상 및 방법

결 과

고 찰

요 약

키워드

Benign childhood epilepsy with centrotemporal spikes Cognition Be-havior Topiramate