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Comparative antiplasmodial activity, cytotoxicity, and phytochemical contents of Warburgia ugandensis stem bark against Aspilia africana wild and in vitro regenerated tissues

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영문명
Comparative antiplasmodial activity, cytotoxicity, and phytochemical contents of Warburgia ugandensis stem bark against Aspilia africana wild and in vitro regenerated tissues
발행기관
(사)한국식물생명공학회
저자명
Okello Denis Gathirwa Jeremiah Wanyoko Alice Komakech Richard Chung Yuseong Gang Roggers
간행물 정보
『Journal of Plant Biotechnology』제50권 제2호, 97~107쪽, 전체 11쪽
주제분류
농수해양 > 기타농수해양
파일형태
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발행일자
2023.06.30
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국문 초록

영문 초록

Malaria remains to be one of the most severe global public health concerns. Traditionally, Aspilia africana and Warburgia ugandensis have been used to treat malaria in several African countries for millennia. In the current study, A. africana calli (AaC), A. africana in vitro roots (AaIR), A. africana wild leaf (AaWL), and W. ugandensis stem bark (WuSB) were dried and pulverized. Fourier transform near-infrared spectroscopy was used to analyze the powdered samples, while 80% ethanolic extracts of each sample were assayed for antiplasmodial activity (against Plasmodium falciparum strains DD2 (chloroquine-resistant) and 3D7 (chloroquine-sensitive)) and cytotoxicity. WuSB showed the highest antiplasmodial activity (IC50 = 1.57 ± 0.210 µg/ml and 8.92 ± 0.365 µg/ml against P. falciparum 3D7 and DD2, respectively) and selectivity indices (43.90 ± 7.914 and 7.543 ± 0.051 for P. falciparum 3D7 and DD2, respectively). The highest total polyphenolic contents (total phenolic and flavonoid contents of 367.9 ± 3.55 mg GAE/g and 203.9 ± 1.43 mg RUE/g, respectively) were recorded for WuSB and the lowest were recorded for AaC. The anti- plasmodial activities of the tested plant tissues correlated positively with total polyphenolic content. The high selectivity indices of WuSB justify its traditional applications in treating malaria and present it as a good candidate for discovering new antimalarial compounds. We recommend elicitation treatment for AaIR, which showed moderate antiplasmodial activity against P. falciparum DD2, to increase its secondary metabolite production for optimal antimalarial activity.

목차

Introduction
Method and Materials
Results
Discussion
Conclusion
Authors’ Contributions
Availability of Data and Materials
Competing Interests
Acknowledgement
References

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APA

Okello Denis,Gathirwa Jeremiah,Wanyoko Alice,Komakech Richard,Chung Yuseong,Gang Roggers. (2023).Comparative antiplasmodial activity, cytotoxicity, and phytochemical contents of Warburgia ugandensis stem bark against Aspilia africana wild and in vitro regenerated tissues. Journal of Plant Biotechnology, 50 (2), 97-107

MLA

Okello Denis,Gathirwa Jeremiah,Wanyoko Alice,Komakech Richard,Chung Yuseong,Gang Roggers. "Comparative antiplasmodial activity, cytotoxicity, and phytochemical contents of Warburgia ugandensis stem bark against Aspilia africana wild and in vitro regenerated tissues." Journal of Plant Biotechnology, 50.2(2023): 97-107

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