항정신병약물 치료에 부분적인 반응을 보인 조현병 환자에 대한 아미설프라이드 병용요법의 효과와 안전성에 관한 연구

• 영문명: Efficacy and Safety of Augmentation Treatment With Amisulpride for Schizophrenic Patients Partially Responsive to Antipsychotics
• 발행기관: 대한신경정신의학회
• 저자명: 김연수 김성곤 김현경 허성영
• 간행물 정보: 『신경정신의학』제61권 제3호, 156~161쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2022.08.31

영문 초록

Objectives The response of schizophrenia or schizoaffective disorder patients to antipsychotics remains insufficient. Therefore, augmentation with additional antipsychotics is common in clinical practice. This study examined the efficacy and safety of amisulpride augmentation in schizophrenia patients partially responsive to antipsychotics. Methods Twenty-nine schizophrenia or schizoaffective disorder patients without treatment response to antipsychotics monotherapy were included in this study. Psychotic symptoms were evaluated using Brief Psychiatry Rating Scale (BPRS), Clinical Global Impression-Severity (CGI-S), and Clinical Global Impression-Improvement (CGI-I). The side effects were evaluated using Barnes Akathisia Rating Scale (BARS) and Simpson-Angus Scale (SAS) at baseline, 4 weeks, 8 weeks, and 12 weeks after the amisulpride augmentation. Results Among the 29 patients, 28 completed the study. At week 12, the mean BPRS score (p<0.001) and CGI-S score (p=0.002) showed significant improvement compared to the baseline. There was no increase in extrapyramidal symptoms according to SAS (p=0.090) and BARS (p=0.137) after the amisulpride augmentation. Conclusion This study demonstrated the efficacy and safety of amisulpride augmentation in schizophrenia or schizoaffective disorder patients partially responsive to antipsychotics. Further studies investigating the efficacy of amisulpride augmentation therapy using placebo control are necessary to confirm the results.

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키워드

조현병 병용요법 아미설프라이드 치료반응 부작용 Schizophrenia Augmentation Amisulpride Response Side effect