H2AX: 유전자 손상 보호자

• 영문명: H2AX: The Guardian of the Genome
• 발행기관: 조선대학교 의학연구원
• 저자명: 아마티아 파머셔 나라얀(Parmeshwar Narayan Amafya) 아카랴 사무드라(Samudra Achaiya) 유호진(Ho-Jin You)
• 간행물 정보: 『The Medical Journal of Chosun University』제32권 제1호, 13~18쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.02.28

영문 초록

The response of eukaryotic cells to double-strand breaks in genomic DNA includes the sequestration of many factors into nuclear foci. Recently it has been reported that a member of the histone H2A family, H2AX, becomes extensively phosphorylated within 10-30 minutes of DNA damage and forms foci at break sites. Histone H2AX has a role in suppressing genomic instability and cancer. Phosphorylated H2AX (gamma-H2AX) is essential to the efficient recognition and (or) repair o f DNA double strand breaks (DSBs)， and many molecules, often thousands, o f H2AX become rapidly phosphorylated at the site of each nascent DSB. gamma-H2AX foci formation is a sensitive biological dosimeter and presents new and exciting opportunities to understand important biological processes, human diseases, and individual variations in radiation sensitivity. These potentialities demonstrate the importance of understanding the parameters and functions of gamma-H2AX formation.

목차

서 론

H2AX의 인산화

Y-H2AX 와 DNA 이중나선절단

H2AX와 DNA복구

유전자 안전성과 세포주기 checkpoint에 대한 H2AX 역할

H2AX의 종양억제 기능

H2AX 기능에 대한 모델

인간 질병과 관련성

키워드

H2AX DNA repair genomic instability Checkpoint