후두 편평세포암종에서 Galectin-1 및 -7의 발현 의의

• 영문명: The Significance of Expression of Galectin-1 and -7 in Squamous Cell Carcinomas of the Larynx
• 발행기관: 조선대학교 의학연구원
• 저자명: 김건형(Gun-Hyung Kim) 강차영(Cha-Young Kang) 윤혁수(Hyuk-Su Yun) 도남용(Nam-Yong Do) 조성일(Sung-Il Cho) 임성철(Sung-C
• 간행물 정보: 『The Medical Journal of Chosun University』제33권 제2호, 158~165쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.06.30

영문 초록

Background and Objectives: The role of different Galectins in the pathogenesis of different types of malignancy is being profoundly investigated recently. In this study, the author investigated the level of Galectin-1 and -7 in the layngeal squamous cell carcinoma tissue to define its relationship to the tumor progression. Materials and Methods: Paraffin-embedded tissue specimens from 77 patients, who were diagnosed as laryngeal squamous cell carcinoma from 1993 to 2007，were immunohistochemically stained for Galectin-1 and -7. Results: Galectin-1 expression was positively correlated with tumor stage and nodal involvement. Galectin-7 expression was increased in better differentiated tumors. Conclusion: Expression of Galectin-1 and -1 can be used as a valuable indicator in laryngeal squamous cell carcinoma under certain limitations.

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키워드

Galectin-1 Galectin-7 Larynx Squamous cell carcinoma