Design of Pro-rich Model Antimicrobial Peptides with Improved Bacterial Selectivity

• 발행기관: 조선대학교 의학연구원
• 저자명: Yong-Hai Nan Song-Yub Shin
• 간행물 정보: 『The Medical Journal of Chosun University』제33권 증보판, 183~187쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.01.31

영문 초록

To develop novel Pro-rich model antimicrobial peptides with shorter length and higher bacterial selectivity/ therapeutic index than a natural Trp/Prᄋ-rich antimicrobial peptide, indolicidin, we synthesized three Prorich model antimicrobial peptides composed of Trp, Lys, Leu and Pro resides. Compared to natural indolicidin, the designed Pro-rich model peptides had approximate 6- to 11 -fold higher bacterial selectivity/ therapeutic index. These designed peptides selectively bind to negatively charged liposomes [L-aphosphatidylethanolamine (EYPE) / L-a-phosphatidyl DL-glycerol (EYPG) (7:3， w /w)]，mimicking bacterial membranes. This result indicated that the high bacterial selectivity of designed Pro-rich model peptides may due to their selective interaction with negatively charged phospholipids. Taken together, our designed peptides appear to be excellent candidates for future development as a novel antimicrobial agent.

키워드

Indolicidin Pro-rich model antimicrobial peptide Bacterial selectivity Therapeutic index