생균제(probiotics)의 이해와 작용기전

• 영문명: Understandings and Mechanisms of Probiotics
• 발행기관: 조선대학교 의학연구원
• 저자명: 문경래(Kyung-Rye Moon)
• 간행물 정보: 『The Medical Journal of Chosun University』제33권 증보판, 91~95쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.01.31

영문 초록

Probiotics are defined as nonpathogenic living microorganisms, including some commensal bacterial flora, which have beneficial effects on host health and disease prevention and/or treatment. They have shown beneficial effects of probiotics on several human diseases, such as antibiotic-associated diarrhea and acute infectious diarrhea, irritable bowel syndrome and atopic dermatitis in children. Most commonly employed probiotics were Lactobacillus GG, Bifidobacterium spp., Streptococcus spp., and the yeast Saccharomyces boulardii. Studies discussed in this review suggest 3 distinct cellular and molecular mechanisms for probiotic regulation : 1) Probiotics block pathogenic bacterial effects by producing bactericidal substances and competing with pathogens and toxins for adherence to the intestinal epithelium; 2) Probiotics regulate immune responses by enhancing the innate immunity and modulating pathogen-induced inflammation via toll-like receptor-regulated signaling pathways; and 3) Probiotics regulate intestinal epithelial homeostasis by promoting intestinal epithelial cell survival, enhancing barrier function, and stimulating protective responses. Significant adverse effects are rare, and there are no known interactions with medications.

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Probiotics