Regulation of Vibrio vulnificus virulence by cyclic AMP-receptor protein

• 발행기관: 조선대학교 의학연구원
• 저자명: Sung-Heui Shin
• 간행물 정보: 『The Medical Journal of Chosun University』제33권 증보판, 65~74쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.01.31

영문 초록

Vibrio vulnificus causes a rapid progressing fatal septicemia with a mortality rate of 50% over. Several V. vulnificus virulence traits are down-regulated by a mutation of the cya gene encoding adenyl cyclase required for the synthesis of cyclic AMP (cAMP) or of the crp gene encoding for cAMP-receptor protein (CRP), and so cya or crp null mutants would be an attractive vaccine candidate. This review briefly summarizes the role of cAMP or CRP in the virulence regulation of V. vulnificus.

목차

Introduction

Catabolite repression

Mutation of cya or crp attenuates several virulence traits of V.vulnificus

Other roles of CRP

Summary and perspectives

키워드

Vibrio vulnificus Virulence regulation Vaccine Cyclic AMP-receptor protein