소아청소년 비만에서 흑색가시세포증의 정도와 위치에 따른 고인슐린혈증 및 인슐린 저항성과의 상관관계

• 영문명: Relation of Acanthosis Nigricans Scales and Locations to Hyperinsulinemia and Insulin Resistance in Obese Children
• 발행기관: 조선대학교 의학연구원
• 저자명: 김호영(Ho Young Kim) 이재희(Jae Hee Lee) 김은영(Eun Young Kim) 양은석(Eun Seok Yang) 박영봉(Yeong Bong Park) 문경래(Ky
• 간행물 정보: 『The Medical Journal of Chosun University』제39권 제4호, 224~231쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.12.31

영문 초록

The aim of this study is to investigate the clinical significance of acanthosis nigricans scales and locations in order to validate the relation of hyperinsulinemia and insulin resistance in obese children. We conducted a retrospective analysis of clinical records of obese children who visited Chosun University Hospital between January 2013 and February 2014 due to their obesity. Five anatomical sites were examined for evaluation of acanthosis nigricans. Clinical characteristics were compared according to the presence and severity of acanthosis nigricans. Among 55 children, 37 children had acanthocis nigricans. A consensus score of acanthosis nigricans was calculated by summing the scores of five locations. The diagnostic categories were: No acanthosis nigricans group, mild group, moderate group, and severe group. Elevated acanthosis nigricans total score showed strong association with elevated BMI, triglyceride, and c-peptide in all groups. Elevated acanthosis nigricans total score also showed strong association with elevated fasting insulin and HOMA-IR. We also found that the neck was the most frequent location of acanthosis nigricans. However, acanthosis nigricans on axilla showed strong association with elevated fasting insulin and HOMA-IR. Estimation of scales and locations of acanthosis nigricans could be useful as a clinical alternative for determining hyperinsulinemia and insulin resistance in obese children.

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키워드

Acanthosis nigricans Hyperinsulinemia Insulin resistance Obese children