Penicillin G 주입이 Furosemide 이뇨작용에 미치는 영향

• 영문명: Effect of Penicillin G on the Diuretic Action of Furosemide in Rabbit
• 발행기관: 대한약리학회
• 저자명: 김인순(I.S. Kim) 이상복(S.B. Lee) 조규철(K.C. Cho)
• 간행물 정보: 『대한약리학잡지』제16권 제2호, 9~14쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1980.12.31

영문 초록

The influence of penicillin G infusion(7.5 units/min/kg) on the diuretic action of furosemide(250μg/kg) in rabbits was studied to investigate the drug interaction between penicillin G and furosemide. The results were as follows: 1) There was no significant change in renal function in the penicillin G infused rabbits compared with the normal ratbit. 2) In comparison with the control group, a significant increase in △U_flow, △U_NaV, △U_kV and△U_clV was noted by 30 minutes following the administration of furosemide in the penicillin G infused group. There was no significant difference in △C_In, △C_PAH between the two groups and △Na⁺ reabsorption rate was significantly decreased in the latter. The potentiating effect of penicillin G on the diuretic action of furosemide should be due to the increased luminal concentration of free form of furosemide, and it may be related to the competitive inhibition of plasma protein binding between the two drugs.