ACTH와 Picrotoxin에 의(依)한 혈당(血糖)과 혈장(血漿) Corticosterone 치(値)의 변동(變動)에 미치는 Chlordiazepoxide의 영향(影響)

• 영문명: Influence of Chlordiazepoxide on the Changes of Blood Sugar and Plasma Corticosterone Level Induced by ACTH and Picrotoxin in Mice
• 발행기관: 대한약리학회
• 저자명: 김영규(Young Gyu Kim) 신만연(Man Ryun Shin)
• 간행물 정보: 『대한약리학잡지』제16권 제2호, 39~44쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1980.12.31

영문 초록

Marc et al. reported that diazepam increased plasma corticosterone level and Dasgupta et al. suggested that chlordiazepoxide(CDP) supressed the adrenal response to ACTH. In this paper, the influence of CDP on the changes of blood sugar and plasma corticosterone level induced by ACTH and picrotoxin were investigated in male mice. The results obtained were summarized as follows; 1) The blood sugar and plasma corticosterone level were increased by CDP, ACTH, and picrotoxin, respectively. 2) The hyperglycemia induced by ACTH and picrotoxin were not affected by the CDP pretreatment. 3) The increase of plasma corticosterone level induced by ACTH was inhibited by the CDP pretreatment. 4) The increase of plasma corticosterone level appeared 30 minutes after picrotoxin injection was slightly enhanced, but the level of 120 minutes after picrotoxin injection was significantly inhibited by the CDP pretreatment.