Etomidoline이 각종 평활근에 미치는 영향

• 영문명: Effect of Etomidoline on the Isolated smooth Muscle of Rabbit
• 발행기관: 대한약리학회
• 저자명: 김원준(W.J. Kim) 김정희(J.H. Kim) 신윤용(Y.Y. Sheen)
• 간행물 정보: 『대한약리학잡지』제16권 제2호, 25~30쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1980.12.31

영문 초록

Etomidoline (Nonspa^？？), which is chemically related to tertiary amine, is new synthetic antispasmodic agent with analgesic action. Antispasmodic effect of this agent is stronger than hyoscine butylbromide (Buscopan^？？), quaternary amine, and the absorption from intestine is also much higher. This study was undertaken to determine the effect of etomidoline on duodenal motility and other smooth muscles of rabbit. Strips of various isolated smooth muscle, 2 cm long from adult rabbits weighting about 2 kg, were suspended in a muscle chamber containing Tyrode s solution, which was bubbled with oxygen gas, and the temperature of the solution was kept constant at 38˚C. After being washed with fresh solution several times the strips of smooth muscle attained constant motility and tonus. Etomidoline and other drugs were added in various concentrations to the chamber. Contractility of the strips was measured by using polygraph (Grass, model 7). The results are as follows: 1) In isolated rabbit atrium etomidoline produces a slight depression of contractility and the rate is also decreased. 2) On the other hand, etomidoline relaxed isolated strips of stomach, duodenal, and detrusor of rabbit. This relaxing effect of etomidoline on isolated duodenal strip of rabbit was not blocked by α-adrenergic blocking agent, phenoxybenzamine, but by β-adrenergic blocking agent, propranolol. 3) Etomidoline did not exert any effect on isolated aorta, gall bladder, and trigone of rabbit. From the above results, it may be concluded that the relaxing effect of etomidoline on duodenal strip is related β-adrenergic receptor.