-G308A Tumor Necrosis Factor-α 유전자 다형성과 주요 우울장애의 연합연구

• 영문명: Possible Association between -G308A Tumor Necrosis Factor-α Gene Polymorphism and Major Depressive Disorder
• 발행기관: 대한신경정신의학회
• 저자명: 배치운 오해정 채정호 박원명 전태연 한훈 김광수
• 간행물 정보: 『신경정신의학』제42권 제2호, 189~193쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2003.03.30

영문 초록

Objectives：The present study was to examine possible association between the -G308A tumor necrosis factor (TNF)-α gene polymorphism and major depressive disorder (MDD) in Korean. Methods：108 inpatients with MDD and 125 healthy controls participated in this study. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism. Results：Genotype and allele distributions in patients with MDD (p=0.02, p=0.01, respectively), were significantly different from those of the controls. Conclusion：The present study suggests that the -G308A TNF-α gene polymorphism may have a potential role for the susceptibility to MDD in Korean population.

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키워드

-G308A TNF-α gene polymorphism Major depressive disorder