비정형 항정신병약물을 투여 중인 정신분열병 환자의 주관적 삶의 질： 정신병리, 약물 부작용 및 약물에 대한 주관적 반응과의 관련성

• 영문명: Subjective Quality of Life in Schizophrenic Patients Receiving Atypical Antipsychotics：Relationship to Psychopathology, Adverse Drug Effects and Subjective Response to Drug
• 발행기관: 대한신경정신의학회
• 저자명: 김종훈 윤정희 이자영 노경희 홍성극 윤세창 강웅구 김용식
• 간행물 정보: 『신경정신의학』제42권 제2호, 222~230쪽, 전체 9쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2003.03.30

영문 초록

Objectives：The purpose of this study was to evaluate the characteristics of psychopathology, adverse drug effects, and subjective response to drugs that have a significant impact on the subjective quality of life in schizophrenic patients receiving atypical antipsychotics. Methods：One hundred and one schizophrenic patients, who were receiving maintenance treatment with atypical antipsychotics, were evaluated. Subjective quality of life was assessed using the standardized Korean modification of a self-rating scale to measure subjective well-being under neuroleptics (KmSWN). Patients’ psychopathology was evaluated using the Positive and Negative Syndrome Scale. Adverse effects and subjective response to drug were evaluated using the Liverpool University Neuroleptic Side Effect Rating Scale and the Drug Attitude Inventory-10, respectively. Correlation analysis and stepwise multiple regression analysis were conducted. Results：In psychopathology, the severity of depression and anxiety showed the most significant correlation with the score of KmSWN. In adverse drug effects, the severity of psychic side effect and extrapyramidal side effect showed the most significant correlation with the score of KmSWN. Regarding subjective response to drug, significant correlation was observed between the severity of subjective negative response and the score of KmSWN. Stepwise multiple regression analysis revealed that psychic side effect, extrapyramidal side effect, and depression contributed significantly to the total score of KmSWN. These variables accounted for 59.7% of the total variance. Conclusion：The results of the present study suggest that psychic side effect, extrapyramidal side effect and depressive symptom are the clinical characteristics that are significantly associated with the subjective quality of life. An effective management strategy for these variables should be established in developing a treatment program to enhance the quality of life of patients with schizophrenia.

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키워드

Quality of life Schizophrenia Psychic side effect Extrapyramidal side effect Depressive symptom