Monocyte Chemoattractant Protein-1(MCP1) -2518 유전자 다형성과 주요 우울장애

• 영문명: Monocyte Chemoattractant Protein-1(MCP1) -2518 Polymorphism and Major Depressive Disorder
• 발행기관: 대한신경정신의학회
• 저자명: 배치운 이지현 신윤경 김태석 김정진 이창욱 이수정 전태연 이철 백인호
• 간행물 정보: 『신경정신의학』제43권 제4호, 381~385쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2004.07.30

영문 초록

Object：This study was designed to examine the association between monocyte chemoattractant protein-1 (MCP1) -2518 polymorphism and major depressive disorder (MDD). Methods：Ninety patients with MDD and 114 healthy controls participated in this study. Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism method. Results：Genotype and allele distributions in patients with MDD were significantly different from those of the controls. In particular, subjects with the allele A were found to have an increased risk of MDD. Conclusion：The present study suggests that the MCP1 -2518 polymorphism may have a potential role for susceptibility to MDD in the Korean population and thus calls for consecutive studies in order to pile up the data with larger different ethnic background.

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키워드

Major depressive disorder MCP1 -2518 polymorphism Korean