조현병 및 비이환 형제에서 피질하 구조물의 변형

• 영문명: Subcortical Deformities in Schizophrenic Patients and Unaffected Siblings
• 발행기관: 대한신경정신의학회
• 저자명: 황승하 김지웅 최지욱 이선우 정범석
• 간행물 정보: 『신경정신의학』제51권 제5호, 241~248쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2012.09.30

영문 초록

ObjectivesZZAbnormalities in various subcortical regions have been reported in previous structural neuroimaging studies for schizophrenia. To understand the subcortical abnormalities as a whole, all subcortical regions should be explored in each subject unlike most previous studies. Here, we explored major subcortical structures using volume measurement and shape analysis for schizophrenic patients (SZ), their unaffected siblings (Sib) and healthy controls without affected sibling (HC). MethodsZZStructural magnetic resonance images were acquired from 24 SZ, 24 Sib and 19 HC. Both segmentation and shape analysis for subcortical structures was performed using FMRIB Integrated Registration and Segmentation Tool integrated within the FSL software. The group comparison of subcortical volumes was performed with multivariate analysis of variance (MANOVA). ResultsZZIn SZ group, shape deformities were observed in the left nucleus caudates, left thalamus, left putamen and bilateral pallidus were increased compared with HC group. In Sib group, shape deformities were observed in the left pallidus, left putamen and left putamen was decreased compared with HC group. In Sib group, left nucleus accumbens was increased compared with SZ group. ConclusionZZThe result of this study using volume measurement and shape analysis suggest that subcortical structural abnormalities in cortico-striato-pallido-thalamic and reward circuits are related with both the pathology of schizophrenia and genetic predisposition.

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키워드

Schizophrenia Unaffected sibling Shape analysis Subcortex Magnetic resonance imaging