조현병의 증상으로 발현한 신생물딸림변연뇌염 1예

• 영문명: A Case of Paraneoplastic Limbic Encephalitis Presented with Schizophrenic Symptoms
• 발행기관: 대한신경정신의학회
• 저자명: 신규식 천은진 이세진
• 간행물 정보: 『신경정신의학』제54권 제4호, 596~599쪽, 전체 4쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2015.11.30

영문 초록

Paraneoplastic limbic encephalitis associated with ovarian teratoma has variable clinical manifestations, including hallucination, abnormal behavior, amnesia, mental change, fever, chorea and dystonia, and often has antibodies to N-methyl-D-aspartate receptor (NMDAR), however cases without tumor or antibodies to NMDAR have also been reported. Here, we describe a 35-year-old female who was initially misdiagnosed as schizophrenia because she presented with acute onset of psychiatric symptoms, including visual hallucination, abnormal behavior, confusion, and memory impairment. Three days after admission, she developed high fever refractory to antibiotics. Brain MRI and examination of cerebrospinal fluid were normal. Computerized tomography of the pelvis showed an ovarian teratoma. The patient showed complete improvement after surgical removal of the ovarian teratoma and steroid therapy. We suggest that physicians should consider the possibility of paraneoplastic limbic encephalitis in patients who present with acute onset of psychiatric symptoms with high fever or movement disorder

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키워드

Limbic encephalitis Paraneoplastic Ovarian teratoma Schizophrenia