한국 성인 남성의 알코올 분해의 약동학적 특징 및 영향요인

• 영문명: Elimination Rate and Pharmacokinetics of Alcohol in Korean Healthy Male Adults
• 발행기관: 대한신경정신의학회
• 저자명: 이보람 남범우 서정석 장성호 이상호 이승환
• 간행물 정보: 『신경정신의학』제54권 제4호, 427~434쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2015.11.30

영문 초록

ObjectivesZZThe objective of this study is to identify alcohol pharmacokinetics and to investigate the correlations between various factors for alcohol metabolism of healthy Korean males. MethodsZZThe 101 recruited volunteers were randomized into two groups as one group provided 0.35 mg/mL/kg and 0.7 mg/mL/kg, the other. Blood alcohol concentration was measured and analyzed in enzymatic methods eight times from drinking point. ResultsZZAlcohol elimination rate (β) was found to be -0.0083%/h for low dose group and -0.0157%/h for the high dose group. The results indicate discrepancy in the legal criteria of alcohol elimination rate (-0.008%/h). The measured alcohol pharmacokinetic properties were following : mean time to reach maximum alcohol concentration in blood was 30 minutes, absorption rate was 0.0197%, maximum alcohol concentration in blood was 0.4930%, and Area under the curve was 59.25. Also, alcohol elimination was not affected by age, smoking, total body water, drinking capacity, body mass index, blood cholesterol, body fat, and body fat ratio. ConclusionZZThese results suggest that legal limitation could be adjusted in Korean males. Also the research should be extended including female and senior citizens for statistical significance of the research. These findings have contributed to our knowledge of the alcohol pharmacokinetics in Korean male.

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키워드

Blood alcohol concentratio Alcohol pharmacokinetics Alcohol elimination rate