정신분열병 환자의 뇌자기공명촬영 소견

• 영문명: Brain MRI Findings in Schizophrenics
• 발행기관: 대한신경정신의학회
• 저자명: 이영봉 정영조 허감
• 간행물 정보: 『신경정신의학』제32권 제6호, 1026~1035쪽, 전체 10쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1993.11.30

영문 초록

To assess whether meaningful structural changes of the brain are present in schizophrenia, the authors evaluated MRI of 10 patients with schizophrenia and 10 controls. Then we measured the several areas of cerebral structures including frontal cortex, cingulate cortex, caudate nucleus, amygdala, hippocampus, parahippocampal gyrus, temporal lobe, third ventricle, lateral ventricle and cerebrum. And the authors designed the study so as to be able to examine the relationships between MRI findings and clinical correlates such as age of onset, duration of illness and positive and negative symptom score and general psychopathology score with PANSS. The results were as follows : 1) There were no significant correlations between the age of onset or the duration of illness and the structural changes of the brain in schizophrenics. 2) Both tempotal lobes, both amygdalas, left caudate nucleus and left parahippocampal gyrus in schizophrenics were significantly smaller than those of control subjects(p<0.05), and third ventricle and VBR in schizophrenics were significantly larger than those of control subjects (p.0.05). 3) Positive symptom scores were positively correlated with right frontal cortex and negatively correlated with right amygdala, and negative symptom scores were negatively correlated with left frontal cortex, right cingulate cortex and both caudate nucleuses. In this study, it was suggested that structural changes of the brain were present in schizophrenia, and these changes were significantly correlated with clinical symptoms but not with any of clinical correlates. So we couldn t make affirmation whether these structural changes acted as the causative factor or were resulted from the course of illness

목차

서 론

연구대상, 연구방법 및 통계처리

결 과

고 찰

결 론

References

키워드

Schizophrenia Brain magnetic resonance imaging Clinical symptoms