주요우울증 환자의 삼환계 항우울제 투여에 따른 임상반응과 뇨 MHPG 및 혈장 Cortis이치와의 관계

• 영문명: The Relationship Between Clinical Response and Urinary MHPG and Plasma Cortisol Level in Major Depressives Treated with Tricyclics
• 발행기관: 대한신경정신의학회
• 저자명: 오영미 황익근
• 간행물 정보: 『신경정신의학』제32권 제6호, 1013~1025쪽, 전체 13쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1993.11.30

영문 초록

The purpose of this study was to examine the effects of tricyclics on urinary M H PG level and plasma cortisol level and to investigate the interaction of noradrenergic system with HPA axis in major depression. The subjects were 24 inpatients with major depression diagnosed according to DSM-III-R. Seventeen medical students and residents served as a control group. 24-hour uinary M H PG and plasma cortisol concentration at 08 : 00 a.m were measured at various points during treatment The results were as follows: 1) No significant difference was found between the urinary MH PG excretion for either depressed patients or comparison subjects. 2) The pretreatment urinary M H PG level and therapeutic response to tricyclic antidepressants did not correlate. 3) Significant positive correlation was found between pretreatment 8 : 00 a.m. plasma cortisol levels and urinary M H PG levels in depressed patients(r=0.54, p<0.05). After tricyclics medication, negative correlation was observed, but was not significant(r= — 0.41，p=N S).

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키워드

Major depression Urinary MHPG Plasma cortisol Noradrenergic system HPA axis