Desipramine 장기투여가 백서 대뇌피질의 Adenylate Cyclase 의 활성도와 GABAb 및 Noradrenaline 수용체후 구조의 Coupling system 에 미치는 영향

• 영문명: Effect of Chronic Desipramine Administration on the Forskalin Stimulated Adenylate Cyclase Activity and the Coupling of GABAb and Norcpinq)hrine-cAMP Generating System
• 발행기관: 대한신경정신의학회
• 저자명: 金唤 薫 橋本桓 栗山欣彌
• 간행물 정보: 『신경정신의학』제33권 제3호, 648~665쪽, 전체 18쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1994.05.30

영문 초록

Long-term treatment of rats with the antidepressant desipramine led to an increase in the potentiation of isoproterenol-induced cAMP accumulation by baclofen in cortical slice. However, the identical treatment with desipramine did not increase in GABAb binding. These results suggest that the mechanism responsible for this potentiation effect is not simply to direct GABAb receptor stimulation. Forskolin-stimulated adenylate cyclase activity increased in cortical slice from rats which received long-term desipramine treatment, while other previous studies have presented inconsistent results. The author assumes that the change of post-5-adrenoceptor component may be more relevant than receptor down-regulation to the therapeutic action of tricyclic antidepressants. However verification of this hypothesis will need further investigation and more elabolate experiments.

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키워드

Desipramine b-Adrenoceptor GABAb receptor Cyclic AMP Forskolin Baclofen