만성 정신분열증 환자에서 항정신병약물 투여에 대한 임상증상과 혈청 Prolactin 치의 반응

• 영문명: Clinical Symptom and Prolactin Response To Neuroleptics in Chronic Schizophrenics 一 To Compare Enlarged Ventricle Group with Normal Ventricle Group ᅳ
• 발행기관: 대한신경정신의학회
• 저자명: 이영호 우경종
• 간행물 정보: 『신경정신의학』제33권 제3호, 599~611쪽, 전체 13쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1994.05.30

영문 초록

Objective : To test the hypothesis that structural change of brain contributes as a biological marker to classify the subtype of schizophrenia by evaluating whether dopaminergic activities are different between normal ventricle group and large ventricle group, and also to confirm that response of serum prolactin to neuroleptics may predict clinical response of symptom in a specific subgroup o f schizophrenia. Methods : Serum prolactin level and psychopathology were measured before neuroleptic administration and at 72hrs, 2wks, and 4wks after medication in 21 chronic male schizophrenicsC 14 normal ventricle group, 7 large ventricle group). Results : The changes of serum prolactin level during the total course of treatment were significant in both groups, but pattern and degree of interval changes were different between the two groups. The changes of positive symptom during the total course of treatment were significant in both groups, but the correlation between serum prolactin level and positive symptom was significant only in normal ventricle group, and change of negative symptom during the total course of treatment were also significant only in normal ventricle group. In normal ventricle group, the early 72hr response of Serum prolactin level to neuroleptics was significantly correlated with overall change of positive symptom Conclusion : Above results suggest that functional abnormalities of dopaminergic pathway rather than changes in amounts of dopaminergic activites are more important in such a subtyping and formation of psychopathology. And these findings lead further support to the hypothesis that structural change of brian may be a meaningful biological marker in subtyping schizophrenia. And in normal ventricular group, the early 72hr response of serum prolactin level to neuroleptics might predict clinical response of positive symptom.

목차

서 론

연구대상 및 방법

연구결과

고 찰

결 론

참 고 문 헌

키워드

Schizophrenia Brain computerized tomography Structural change Serum prolactin response Clinical response