항정신병 약물로 인한 지연성 근긴장 이상의 유병율

• 영문명: Prevalence of Tardive Dystonia
• 발행기관: 대한신경정신의학회
• 저자명: 최정미 장대식 김종길
• 간행물 정보: 『신경정신의학』제30권 제4호, 710~719쪽, 전체 10쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1991.07.31

영문 초록

Tardive dystonia is a rare late-onset side effect o f neuroleptics. This report presents a prevalence study o f 1520 inpatients conducted in 4 mental sanatoriums in Pusan City and Kyung N am province. O ur criteria for diagnosing tardive dystonia (by Burke et, 1982) were 1) presence o f chronic dystonia 2) history of antipsychotic drug treatment preceding or concurrent with the onset o f dystonia 3) exclusion o f known causes o f secondary dystonia by appropriate clinical and laboratory evaluation 4) a negative family history o f dystonia. Tardive dystonia was also assessed using Simpson rating scale for Tardive dyskinesia. For exclusion of other known causes of secondary dystonia, several studies(liver function test thyroid function test determination of serum copper & ceruloplasmin level, observation of Kayser-Fleisher ring) were performed. The results were as follows : 1) Twenty-one of the 1520 assessed patients have been suffered from manifestation of tardive dystonia(l.3 8% ).; sixteen of 1009 men(1.59%) and five of 511 women(0.98%). Sexual prevalence rate was not tatistically significantCx2—0.92). 2) Eighteen patients among 347 patients less than 40 years old developed tardive dystonia (5.2%) as compared to 3 patients of 1173 over the age o f 40(0.3%). This remarkable difference among young aged before 40 years old is highly significantCx2—with Yate’s correction = 44.25) (p<0.001). 3) The most frquently affected site was neck(90.5%), the next, head(61.9%), trunk(33.3%) and extrimities(4.8%). 4) Five patients had concurrent tardive dyskinesia (28.5%) head nodding, eye blinking， finger tremor, stamping movement, puckering and smacking were observed. The severity of tardive dystonia fluctuated without unifofm pattern and aggravated when anxious or tense. 5) Duration of exposure to antipsychotics was varied from 3 months to 24 years (mean 5.6土 1.60 years). Seventeen of 21 patients have been taken chloropromazine

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