일산화탄소가 신생백서의 [3H] 5-hydroxytryptamine 결합부위에 미치는 영향

• 영문명: The Effect of Carbon Monoxide on the 〔3H〕5-hyroxytryptamine Binding Sites in Neonatal Rats
• 발행기관: 대한신경정신의학회
• 저자명: 김용식 정배연 조수헌
• 간행물 정보: 『신경정신의학』제30권 제4호, 652~659쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1991.07.31

영문 초록

This study was performed to observe the effect of carbon monoxide on the [3H] 5-HT binding sites in neonatal rat brains during each developmental stage. 5 day old and 6 week old Sprague-Dawley rats were exposed to 0.42% carbon monoxide. The rats were sacrificed immediately, after 24 hours, after 1 week, and at 16 weeks of age. Cortex, hippocampus, and striatum were dissected for two point assay with InM and lOnM of [3H] 5-HT. Scatchard analysis was done for the cortices of those rats exposed to air or carbon monoxide when they were 5 days old and sacrificed after 24 hours and at 16 weeks of age, and also those rats, exposed when they were 6 weeks old and sacrificed at 16 weeks of age. We did not find any statistically significant difference between the carbon monoxide and air group at each different condition in two point assay and in Scatchard analysis. We did observe the trend that carbon monoxide can influence persistently upon [3H] 5-HT binding sites in neonatal rats, which deserves further study.

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