座攀性 腦-電氣衝擊에 의한 생쥐 視床下部 및 腦幹의 Monoamine 代謝의 變動에 관한 研究

• 영문명: Effects of Single and Repeated Electroconvulsive Shock on the Hypothalamus and Brain Stem Contents of Monoamine Metabolites in Mice
• 발행기관: 대한신경정신의학회
• 저자명: 朴青 山 申灵 浩 李明雅 全普權
• 간행물 정보: 『신경정신의학』제30권 제4호, 660~670쪽, 전체 11쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1991.07.31

영문 초록

Male ICR mice ranging from 15g to 20g were given a single ECS( 1-ECS * 13mA, lsec, lOOcps) daily or on alternate days for 10 days(5-ECS). The contents of monoamine metabolites in the hypothalamus and the brain stem(BS) were measured 10，30, and 60 min after ECS-administration as well as before ECS. Contents of monoamine metabolites in the HT and the BS, such as 5-HIAA, MHPG, DOPAC and HVA increased rapidly after 1-ECS or 5-ECS and then came down to the pre-ECS values. However, their increases induced by 5-ECS were significantly smaller than those by 1- ECS except the tedious increase of the hypothalamic HAV content. 5-HIAA and MHPG in the HT decrease significantly by the 4th administration of ECS in the course of the 5-ECS treatment. These results suggest that the repeated treatment of ECS may decrease the turnover rates of serotonin and noradrenaline in the hypothalamus

목차

서 론

실험재료 및 방법

실 험 성 적

고 찰

결 론

References