Doxepin이 가토 혈중 주정농도에 미치는 영향에 관한 실험적 연구

• 영문명: Effects of Doxepin on Blood Alcohol Level in Rabbits
• 발행기관: 대한신경정신의학회
• 저자명: 박기창
• 간행물 정보: 『신경정신의학』제21권 제3호, 448~454쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1982.08.31

영문 초록

Doxepin is a tricyclic antidepressant and is a derivative of dibenzoxepine, which is known to be effective in depressed patients, showing anxiety and sleep disturbance. The author conducted an animal experiment to investigate the effects of this antidepressant on blood alcohol level, because many investigators have suggested that any new psychotropic drug should be tested for their interaction with alcohol. The expermient was done on mature rabbits of both sexes. The control group was given alcohol alone, and the experimental groups were given not only alcohol but also various oral doses of doxepin, namely, 10mg/kg for 5 days, 10 mg/kg for 10 days, 25mg/kg for 5 days, and 25mg/kg for 10 days, respectively. The last dose was given one and a half hour before alcohol administration. In all groups, 5. Oml/kg of 2096 ethanol solution was given intravenously and at 15 and 45 minutes after alcohol injection, blood specimens were obtained by cardiac puncture. The blood alcohol levels were determined by Cavett’s method. Doxepin, when administered orally in a dose of lOmg/kg of body weight daily for 5 or 10 days, did not change the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration, but when administered orally in a dose of 25mg/kg of body weight daily for 5 or 10 days, elevated the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration. It is concluded that doxepin elevates the blood alcohol level in rabbits at a high dose.

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실험재료 및 실험방법

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