Nomifensine과 Amitriptyline의 臨床的 比較硏究

• 영문명: A Comparative Clinical Study of Nomifensine and Amitriptyline
• 발행기관: 대한신경정신의학회
• 저자명: 李定均 李壽喆
• 간행물 정보: 『신경정신의학』제21권 제3호, 391~395쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1982.08.31

영문 초록

1. Nomifensine, an isoquinoline dopaminergic agonist, was investigated in a randomized single blind group comparison with amitriptyline in 23 patients with depression. The dosage schedule was a flexible one, with a daily dose range from 50 to 250mg for bo th groups. 2. Assessments were made at biweekly intervals for 4 weeks using the check list with 45 items. 3. Nomifensine was shown to be as effective as amitriptyline in relieving depression. Nomifensine, however, showed a trend toward more rapid effect and a little lesser late effect. 4. Neither drug produced serious unwanted side effects. But nomifensine was relatively more free of side-effects. 5. Results of our study have to be generalized with caution because of limited sample size.

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