Lithium과 항정신병 약물의 병합치료에 의하여 발생된 급성 뇌증후군

• 영문명: Acute Organic Brain Syndrome due to Combined Use of Lithium and Neuroleptics
• 발행기관: 대한신경정신의학회
• 저자명: 이창욱 채영래 백인호
• 간행물 정보: 『신경정신의학』제28권 제4호, 551~555쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1989.07.31

영문 초록

The authors studied the characteristics of the acute brain syndrome induced by lithium-neuroleptic combined treatment in manic patient, admitted to the Neuropsychiatric Department of Kang-Nam St. Mary’s Hospital from January 1981 to December 1987. Among 204 manic patients who had been treated with lithium and neuroleptics, 9 subjects showed acute brain syndrome. The charateristics and risk factors of acute brain syndrome subjects were analyzed, and the results were as follows; Acute brain syndrome appeared within 2 weeks follwing combined therapy of lithium and neuroleptics, even though serum lithium level were maintained within therapeutic ranges. Following the discontinuation of the drugs acute brain syndrome completely disapperared within 1 week. This findings strongly suggest that the acute brain syndrome seems to be an idiosyncratic response to the lithium-neuroleptic interaction.

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