치매 환자에서의 자율신경기능 이상

• 영문명: Autonomic Dysfunction in Patients With Dementia
• 발행기관: 대한노인정신의학회
• 저자명: 이지민(Jimin Lee) 장성만(Sung Man Chang)
• 간행물 정보: 『노인정신의학』노인정신의학 제25권 제2호, 57~64쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2021.10.30

영문 초록

Autonomic dysfunction commonly occurs in patients with dementia and is typically reported in patients with Alzheimer’s disease and Lewy body dementia. The clinical presentation of autonomic dysfunction includes symptoms related to orthostatic hypotension (manifested as dizziness, falls, and syncope, etc.), constipation, and urinary tract symptoms. Non-pharmacological management of orthostatic hypotension should include bolus water drinking. Pharmacological management includes the administration of midodrine (selective α1-adrenoceptor agonist), droxidopa (norepinephrine prodrug), or atomoxetine (selective noradrenaline reuptake inhibitor). Management of constipation includes the administration of probiotics, osmotic laxatives (e.g. macrogol), and type-2 chloride channel activators (e.g. lubiprostone), and management of urinary tract symptoms includes the administration of mirabegron (selective β3-adrenergic receptor). Autonomic dysfunction interferes with daily activities and negatively affects patients’ and caregivers’ quality of life. Therefore, early diagnosis of autonomic dysfunction and prompt initiation of optimal treatment are important to improve patients’ quality of life and prognosis

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자율신경계 치매 기립성 저혈압 하부 요로 증상 루이소체병 Autonomic nervous system Dementia Orthostatic hypotension Lower urinary tract symptoms Lewy body disease