초기 인지저하 단계에서 변화가 확인되는 신경심리영역

• 영문명: Neuropsychological Domains Altered at the Early Stage of Cognitive Decline
• 발행기관: 대한노인정신의학회
• 저자명: 김진현(Jinhyun Kim) 박수진(Soo Jin Park) 이도엽(Do Yup Lee) 하정희(Junghee Ha)
• 간행물 정보: 『노인정신의학』노인정신의학 제25권 제2호, 105~112쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2021.10.30

영문 초록

Objective: A neuropsychological battery is a gold standard for thorough cognitive evaluation. However, it could not be used as a screening test due to its long inspection time and high cost. This study is conducted to identify specific cognitive subdomains that alter even at the early stage of cognitive decline. Methods: Neuropsychological battery results of 575 persons who visited memory clinic were analysed. We classified stages of cognitive decline according to Clinical Dementia Rating (CDR) and CDR-Sum of boxes (CDR-SB). To explore which subdomains can sensitively distinguish normal cognition from the early cognitive impairment, we used Variable Importance in Projection (VIP) in addition to analysis of covariance. Results: We found that scores in subdomain tests such as Rey Complex Figure Test immediate and delayed recall successfully differentiate persons with CDR 0 from those with CDR 0.5 and also persons with CDR-SB 0 from those with CDR-SB 0.5 as indicated by VIP values greater than 1. Conclusion: These results suggest that alterations in visuospatial memory function might be a sensitive sign reflecting the early cognitive decline. The combination of only a few subtests could be also used as a reliable and sensitive screening tool to detect early cognitive impairment.

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키워드

인지저하 치매 신경심리검사 질병조기발견 공간기억 Cognitive decline Dementia Neuropsychological tests Early detection of disease Spatial memory