Association of Sub-Threshold Amyloid Retention With Neuropsychological Performance in Cognitively Normal Older Adults Without the APOE ε4 Allele

• 발행기관: 대한노인정신의학회
• 저자명: Ji Won Choi Sheng-Min Wang Yoo Hyun Um Hae-Ran Na Nak-Young Kim Hyun Kook Lim Chang Uk Lee Dong Woo Kang
• 간행물 정보: 『노인정신의학』노인정신의학 제25권 제2호, 76~82쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2021.10.30

영문 초록

Objective: Recent evidence shows that the quantitative value of amyloid-beta (Aβ) deposition below the threshold of Aβ positivity carries biological and clinical significance regarding future cognitive decline. We evaluated whether the quantitative value of subthreshold Aβ deposition had a significant correlation with neuropsychological test scores in cognitively normal older adults without the APOE ε4 allele. Methods: Sixty cognitively normal APOE ε4 allele non-carriers with negative Aβ retention aged 60 to 85 years were included in this study. We assessed neuropsychological performance with the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD-K) and obtained standardized [18F] flutemetamol uptake values in the pons as a reference (SUVRPONS), evaluated with PET. Multiple regression analyses were conducted to assess the effect of global and regional Aβ load on cognitive performance, adjusting for age, sex, years of education, and volumes of white matter hyperintensities. Results: We found that Aβ deposition in the precuneus, posterior cingulate cortex, and parietal lobe had a significant association with the total CERAD-K scores. There was also a significant correlation between the SUVRPONS in the precuneus and the CERAD-K total score after Bonferroni correction. Conclusion: Subthreshold Aβ retention in the core brain regions of the default mode network could affect cognitive functions in the cognitively normal APOE ε4 non-carriers, considered to be the lowest risk group for Alzheimer’s disease (AD).

목차

Introduction

Subjects and Methods

Results

Discussion

키워드

Amyloid Cognition Apolipoprotein ε4 Flutemetamol Aged