알츠하이머병에서 혈장 크레아틴과 염증반응, 인지기능과의 연관성

• 영문명: Association of Plasma Creatine With Inflammation and Cognitive Function in Persons With and Without Alzheimer’s Disease
• 발행기관: 대한노인정신의학회
• 저자명: 김민애(Minae Kim) 오대종(Dae Jong Oh) 김현정(Hyunjeong Kim) 조소연(So Yeon Cho) 하정희(Junghee Ha) 이준영(Jun-Young Lee) 김어수(Eosu Kim) 김근유(Keun You Kim)
• 간행물 정보: 『노인정신의학』노인정신의학 제25권 제2호, 98~104쪽, 전체 7쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2021.10.30

영문 초록

Objective: Creatine, energy buffer in high energy demanding systems including muscle and brain, may play a beneficial role against neuroinflammation in Alzheimer’s disease (AD), and thus be a potential biomarker. This study aimed to compare the levels of plasma creatine between persons with and without AD and investigate associations of plasma creatine levels with cognitive function and blood-based inflammatory markers. Methods: We classified elderly participants by cognitive statuses: normal cognition (NC, n=17), mild cognitive impairment (MCI, n=21), and AD (n=21). To assess cognitive function and inflammatory condition, we performed neuropsychological tests and measured plasma C-reactive protein (CRP) levels, respectively. Results: Plasma creatine levels were comparable among participants with AD, MCI, and NC. In overall participants, plasma creatine levels were not associated with neuropsychological test scores, but negatively associated with plasma CRP levels. In AD group, plasma creatine levels were negatively associated with neuropsychological test scores and, although not significant, CRP levels (p=0.086). In participants without AD (NC plus MCI), these associations disappeared. Conclusion: Plasma creatine levels may not be useful as a biomarker indicating cognitive statuses. However, our results suggest that, in AD, plasma levels of creatine might reflect the extent of neuroinflammation as well as cognitive deterioration.

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키워드

크레아틴 알츠하이머병 치매 인지 염증 C반응단백질 Creatine Alzheimer’s disease Dementia Cognition Inflammation C-reactive protein