근적외분광분석법을 이용한 의약품 건조공정 중 실시간 수분함량 모니터링

• 영문명: Online Real-Time Monitoring of Moisture in Pharmaceutical Granules During Fluidized Bed Drying Using Near-Infrared Spectroscopy
• 발행기관: 대한약학회
• 저자명: 김재진(Jaejin Kim) 김병석(ByungSuk Kim) 임영일(YoungIl Lim) 우영아(YoungAh Woo)
• 간행물 정보: 『약학회지』제60권 제2호(2016년), 85~91쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2016.03.31

영문 초록

Drying of granules for tablet formulation is one of the important unit operations. The loss on drying method is traditionally used for this purpose. However, it is a time-consuming method, requiring at least 1 h. Moreover, it is ineffective in monitoring the moisture content of granules during the drying process. In this study, online real-time monitoring of moisture content during the drying process was successfully performed using near-infrared (NIR) spectroscopy. NIR spectra were collected during 15 different drying batches for developing a reliable NIR spectroscopic method. Such a large number of batches were used to develop a more robust partial least squares (PLS) model. NIR spectra collected from 12 batches were used for developing the model that was validated by predicting the moisture content of the samples in the remaining 3 batches. The standard errors of predictions (SEPs) in the measurement of batch 1, batch 2, and batch 3 were 0.52%, 0.57%, and 0.56%, respectively. The online NIR spectroscopic method developed in this study was reliable and accurate in monitoring the moisture content during the drying process.

목차

Abstract

실험 방법

결과 및 고찰

결 론

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키워드

drying process near-infrared spectroscopy Process Analytical Technologies (PAT) real-time monitoring fluidized bed drying