기니픽에서 정제봉독겔의 광독성 평가

• 영문명: Antigenicity of Purified Bee Venom Gel from Honeybee (Apis mellifera L.) in Guinea Pigs
• 발행기관: 대한약학회
• 저자명: 한상미(SangMi Han) 홍인표(InPhyo Hong) 우순옥(SoonOk Woo) 김세건(SeGun Kim) 장혜리(HyeRi Jang) 박관규(KyunKyu Park)
• 간행물 정보: 『약학회지』제60권 제2호(2016년), 53~57쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2016.03.31

영문 초록

This study was performed to examine the skin phototoxicity of purified bee venom (Apis mellifera L.) collected using bee venom collector. To confirm whether the gel containing purified bee venom (BV gel) causes photototoxicity when used for the skin medicinal products, phototoxicity testing was conducted using guinea pig models. The BV gel (0.1 ml/site) was administered transdermally to guinea pigs. 8-MOP was used to introduce positive control response. After administration, the guinea pigs were irradiated with UVA (15 J/cm2) with doses based on standard phototoxicity study guidelines. In the weight measurement and clinical observation, BV gel groups didn’t show any significant changes compared with control group. BV gel groups did not show any symptoms such as erythema and edema formation of skin. This study demonstrated that BV gel has promising potential external treatment for topical uses that do not induce significant levels of skin phototoxicity.

목차

Abstract

실험 방법

실험 결과 및 고찰

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감사의 말씀

References

키워드

honeybee venom phototoxicity guinea pigs erythema edema