시판중인 메트릭스 정제의 팽윤력 비교 연구

• 영문명: Swelling of Commercial Matrix Tablets Based on Carboxymethyl Cellulose Sodium and Alginic Acid
• 발행기관: 대한약학회
• 저자명: 김기택(KiTaek Kim) 김지수(JiSu Kim) 박주환(JuHwan Park) 이재영(JaeYoung Lee) 조영우(YeongWoo Jo) 양재권(JaeGwon Yang) 장준희(JunHee Jang) 최은선(EunSun Choi) 김대덕(DaeDuk Kim)
• 간행물 정보: 『약학회지』제60권 제2호(2016년), 73~77쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2016.03.31

영문 초록

Alginic acid and carboxymethyl cellulose sodium are dietary fibers from plants. They have a swelling property and delay the gastric emptying time, thereby resulting in feeling satiated after oral administration, which may eventually contribute to loss of body weight. The goal of this study was to compare swelling property of three commercial matrix tablets based on alginic acid and carboxymethyl cellulose sodium. When the swelling was determined by the Korean Ministry of Food and Drug Safety (MFDS) guideline, the tablet prepared by direct compression method with highly viscous swelling agent showed the highest swelling in acidic conditions. Water uptake of these tablets was rapid and completed within 30 min. Moreover, when the pH was changed from 2.5 to 6.8 buffer, the water uptake was not significantly changed in all tablets.

목차

Abstract

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감사의 말씀

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키워드

alginic acid carboxymethyl cellulose sodium tablet swelling water uptake