종양괴사인자로 유도된 기도 뮤신 생성, 뮤신 유전자 발현 및 NF-κB p65의 핵으로의 이동에 대한 크리신의 영향

• 영문명: Effect of Chrysin on Tumor Necrosis Factor-α-induced Mucin Production, Mucin Gene Expression and Translocation of Nuclear Factor-kappa B in Cultured Airway Epithelial Cells
• 발행기관: 대한약학회
• 저자명: 신현대(Hyun-Dae Shin) 이현재(Hyun Jae Lee) 무함마드 아사두자만 식더(Md. Asaduzzaman Sikder) 류지호(Jiho Ryu) 박수현(Su Hyun Park) 홍장희(Jang-Hee Hong) 석정호(Jeong Ho Seok) 이충재(Choong Jae Lee)
• 간행물 정보: 『약학회지』제56권 제3호 (2012년), 198~203쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.06.30

영문 초록

Chrysin and chlorogenic acid are natural products derived from Scutellariae Radix and Lonicerae Flos, respectively. We examined whether chrysin and chlorogenic acid affect airway mucin production induced by TNF-α in NCI-H292 cells. Cells were pretreated with each agent for 30 min and then stimulated with TNF-α for 24 h. Of the two compounds, chrysin suppressed airway MUC5AC mucin production. Also, chrysin suppressed MUC5AC mucin gene expression and translocation of NF-κB p65 induced by TNF-α. This result suggests that chrysin can regulate the production and gene expression of mucin induced by TNF-α through the inactivation of NF-κB in airway epithelial cells.

키워드

airway mucin chrysin