LC/MS/MS를 이용한 혈장 중 리도카인의 정량 및 리도카인 패치제의 약물동태학적 평가

• 영문명: LC/MS/MS Method for the Determination of Lidocaine in Hairless Rat Plasma and Pharmacokinetic Applications of Lidocaine Patch
• 발행기관: 대한약학회
• 저자명: 황지연(Ji-yeon Hwang) 김철준(Chul-Jun Kim) 신영희(Young-hee Shin)
• 간행물 정보: 『약학회지』제56권 제3호 (2012년), 158~163쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.06.30

영문 초록

Lidocaine has been studied for many chronic pain conditions, including postherpetic neuralgia (PHN) and recently it has also been increasingly used in transdermal drug delivery systems. In this study, harmacokinetics of a lidocaine patch was studied in four hairless male rats. The plasma concentration was determined by a validated LC/MS/MS method after applying a 3×2 cm2 (30mg) patch for 12 hours. From the plasma lidocaine concentration vs time curves, AUC0-20h, Cmax, and Tmax of lidocaine patch were 2,926.32±335.28 ng · h/ml, 256.86±29.63 ng/ml, and 6.00±2.31 h, respectively.

키워드

LC/MS/MS assay lidocaine patch pharmacokinetics hairless rat