목향에탄올추출물의 ROS-MAPKs 경로를 통한 세포사멸 유도

• 영문명: Ethanol Extract of Saussurea lappa Root Induces Apoptosis through an ROS-MAPKs-Linked Cascade
• 발행기관: 대한약학회
• 저자명: 김대성(Dae-Sung Kim) 이성진(Sung-Jin Lee) 이장천(Jang-Cheon Lee) 우원홍(Won-Hong Woo) 임규상(Kyu-Sang Lim) 문연자(Yeun-Ja Mun)
• 간행물 정보: 『약학회지』제56권 제3호 (2012년), 173~179쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.06.30

영문 초록

Saussurea lappa (SL) and major compounds, sesquiterpene lactones, have been suggested to possess various biological effects, including anti-tumor, anti-ulcer, anti-inflammatory, anti-viral and cardiotonic activities. Therefore, the ethanol extract of Saussurea lappa root (ESL) is studied for the mechanism of its action in apoptotic pathway. ESL-treated cells manifested nuclear condensation, and fragmentation. ESL also triggered the mitochondrial apoptotic pathway, as indicated by a change in Bax/Bcl2 ratio and caspase-9/-3 activation. ESL induced p38 MAPK/JNK, p53, and ASK1 phosphorylation. ROS scavenger reversed ESL-induced apoptotic cell death via inhibition of caspase-3 and p38 MAPK/JNK phosphorylation. These results suggest that ESL induced apoptosis in HepG2 cells through the ROS-p38/JNK pathway.

키워드

Saussurea lappa Bax/Bc12 caspases MAPKs apoptosis