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• 영문명: Microemulsion Fomulation for Enhanced Topical Absorption of Root Extract of Angelica gigas
• 발행기관: 대한약학회
• 저자명: 정은재(Eun-Jae Jung) 최준호(Joonho Choi) 박충범(Chun-Geon Park) 최애진(Ae-Jin Choi) 정세호 정석재(Suk-Jae Chung) 심창구(Chang-Koo Shim) 김대덕(Dae-DuK Kim)
• 간행물 정보: 『약학회지』제56권 제3호 (2012년), 152~157쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.06.30

영문 초록

Angelica gigas is one of the most widely used herbal medicines in Asia. Root extract of Angelica gigas is known to have anti-oxidant activity and skin whitening effect. The aim of this study was to prepare microemulsion system of root extracts of Angelica gigas for topical delivery. Microemulsion was successfully prepared by using MCT (medium chain triglyceride) as an oil phase, Labrasol as a surfactant, and the mixture of propyleneglycol and phosphatidylcholine (4 : 1) as a cosurfactant. In vitro and in vivo skin permeation and deposition of decursin, as a marker, was determined using hairless mouse. Microemulsion significantly increased the in vitro skin permeation of decursin for up to 12 hours and was significantly higher than the control (water). Moreover, microemulsion formulation showed significantly higher skin deposition of decursin compared to the control in both in vitro and in vivo studies. Thus, microemulsion could be a useful vehicle for topical application of root extracts of Angelica gigas.

키워드

Angelica gigas Decursin Topical delivery Microemulsion