대장암 세포주에서 메타아비산 나트륨에 의한 G1 세포주기 정지

• 영문명: Sodium Metaarsenite (KML001) Induces G1 Phase Arrest in HCT116 Colorectal Cancer Cells
• 발행기관: 대한약학회
• 저자명: 홍윤경(Yunkyung Hong) 김선미(Sunmi Kim) 이승훈(Seunghoon Lee) 강재선(Jae Seon Kang) 홍용근(Yonggeun Hong)
• 간행물 정보: 『약학회지』제55권 제5호 (2011년), 391~397쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.10.31

영문 초록

KML001 reduced the proliferation of HCT116 cells in a concentration- and time-dependent manner without change of cell viability. Beclin-1 expression was significantly attenuated by KML001 (P<0.05), but no significant changes were observed in KML001-treated cells. The number of cells in G1 phase was increased 48 hr after KML001 treatment. Furthermore, a dramatic reduction in the frequency of beating and the number of embryoid bodies of the cells was noted after treatment. Taken together, KML001 suppresses the proliferation of HCT116 cells, which might be due to G1 phase arrest.

키워드

KML001 colorectal cancer cell G1 phase arrest cardiac toxicity