발효보중익기탕들의 생물전환성분 분석

• 영문명: Analysis of Bioconversion Compositions from Fermented Bojungikki-tangs
• 발행기관: 대한약학회
• 저자명: 김동선(Dong-Seon Kim) 노주환(Joo-Hwan Roh) 조장원(Chang-Won Cho) 마진열(Jin Yeul Ma)
• 간행물 정보: 『약학회지』제55권 제5호 (2011년), 361~366쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.10.31

영문 초록

Traditional herbal medicinal preparation Bojungikki-tang (BJT) is well-known herbal medicine used as tonic. We fermented Bojungikki-tang using nine lactic acid bacteria strains and discovered two remarkably increased compositions from the fermented BJTs using HPLC/DAD analysis. HPLC/DAD-guided fractionation of the increased compositions followed by structure identification using NMR and MS identified liquiritigenin and isoliquiritigenin. These bioconversion compositions were quantitatively analyzed using HPLC-DAD. Liquiritigenin contents were highest in BJTs fermented with L. amylophilus (1.91 mg/g) and L. fermentum (1.89 mg/g), which were increased by 20-fold compared to BJT (0.09 mg/g). Isoliquiritigenin contents were highest in BJTs in fermented with L. plantarum (0.19 mg/g) and L. fermentum (0.19 mg/g), which were increased by 19-fold compared to BJT (0.01 mg/g).

키워드

Bojungikki-tang fermentation herbal medicine bioconversion liquiritigenin isoliquiritigenin