발효 갈근탕과 쌍화탕의 혈소판 응집 억제 효과 연구

• 영문명: Anti-platelet Aggregation Study of Fermented Galgeun Tang and Fermented Ssanghwa Tang
• 발행기관: 대한약학회
• 저자명: 손추영(Chu-Young Son) 송병정(Byung-Jeong Song) 마진열(Jin Yeul Ma) 권광일(Kwang-Il Kwon)
• 간행물 정보: 『약학회지』제55권 제5호 (2011년), 374~378쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.10.31

영문 초록

This study was performed to evaluate enhanced effect of fermented Galgeun tang (GGT) and Ssanghwa tang (SHT) on the anti-platelet aggregation. Platelet aggregation assay was performed In vitro using human platelet rich plasma(PRP) and In vivo using SD-rat plasma by platelet aggregometer. Pharmacodynamic parameters, Emax and EC50, were calculated using Winnolin. SD-rats administered 1 g/kg of oriental medicine every 12 hr for 8 days. Platelet aggregation was measured by optical method with collagen inducer (4 μg/ml). In In vitro anti-platelet study, EC50 of GGT-A was lower than that of GGT-con about 79.13 μg/ml. And EC50 of SHT-A and SHT-B was lower than that of SHT-con about 122.73 and 110.15 μg/ml, respectively. It is assumed that fermented GGT and SHT were more effective than original medicine. In multiple administration study, anti-platelet effect was significantly increased both GGT and SHT. Fermented GGT and SHT were more effective than original herbal medicine on anti-platelet aggregation.

키워드

Galgeun tang Ssanghwa tang fermentation anti-platelet original medicine