그람양성세균에 대한 새로운 퀴놀론계 항균제 Zabofloxacin의 항균력

• 영문명: Antibacterial Activity of Zabofloxacin, a Novel Fluoroquinolone, against Gram-Positive Bacteria
• 발행기관: 대한약학회
• 저자명: 박희수(Hee Soo Park) 정성지(Sung Ji Jung) 정지웅(Ji-Woong Jeong) 최동락(Dong-Rack Choi) 김효현(Hyo-Hyun Kim) 최응칠(Eung-Chil Choi) 곽진환(Jin-Hwan Kwak)
• 간행물 정보: 『약학회지』제55권 제1호 (2011년), 11~15쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.02.28

영문 초록

Zabofloxacin is a novel broad spectrum fluoroquinolone with excellent anti-pneumococcal activity. We investigated the in vitro activity of zabofloxacin against clinical isolates of gram-positive bacteria and the in vivo activity against systemic infection in mice. Zabofloxacin was very active against gram-positive bacteria except QRSA (Quinolone-resistant S. aureus) and VRE(Vancomycin-resistant Enterococci). Especially, zabofloxacin was extremely potent against clinical isolates of Streptococci. Zabofloxacin was as active as gemifloxacin against systemic infection in mice. In view of its improved antibacterial activities against gram-positive bacteria and good pharmacokinetic profiles in animals, the clinical usefulness of zabofloxacin should be established by further studies.

키워드

zabofloxacin fluoroquinolone gram-positive bacteria MIC in vivo activity