아미오다론에 의한 윤생각막병증의 공초점주사현미경 소견

• 영문명: In Vivo Confocal Microscopic Findings of Corneal Tissue in Amiodarone-Induced Vortex Keratopathy
• 발행기관: 대한안과학회
• 저자명: 이재정 최범석 박영민 이종수,Jae Jung Lee, MD, Beom Seok Choi, MD, Young Min Park, MD, Jong Soo Lee, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume56,number1, 127~133쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2015.01.15

영문 초록

Purpose: To analyze the morphology of corneal tissue in patients with Amiodarone-induced vortex keratopathy by in vivo confocal microscopy (IVCM). Case summary: Four eyes of 2 patients with clinically diagnosed Amiodarone-induced vortex keratopathy were examined using corneal topography and IVCM. Cross-sectioned corneal images of the corneal epithelium, Bowman's layer, stromal layer, Descemet's membrane, and endothelium were evaluated. Location of corneal deposits examined by conventional slit-lamp microscopy was correlated with findings of corneal topography. The curvature map of corneal topography revealed an unusual irregular astigmatism with generalized mild steepening consistent with the location of the corneal deposits and the elevation map showed the change of corneal elevation according to the corneal deposits. Multiple hyper-reflective whitish dots were found at the corneal epithelial level and some were found at the anterior stromal level. Regarding the corneal endothelial layer, case 1 demonstrated normal corneal endothelial tissue, but case 2 showed several hyper-reflective whitish dots in the endothelium. Conclusions: In patients with Amiodarone-induced vortex keratopathy, IVCM showed corneal deposits in the corneal epithelium, stroma, and endothelium. Distribution of microdeposits in the corneal tissue caused an irregular astigmatism. J Korean Ophthalmol Soc 2015;56(1):127-133

키워드

Amiodarone-induced keratopathy, Confocal microscopy, Vortex keratopathy