분지망막정맥폐쇄에 동반된 황반부종 환자에서 덱사메타손 유리체강내 삽입물의 단기임상결과

• 영문명: Short-Term Outcome of Intravitreal Dexamethasone Implant for Macular Edema Secondary to Branch Retinal Vein Occlusion
• 발행기관: 대한안과학회
• 저자명: 강선아 김종우 김철구 이태곤 유영주 김재휘,Sun Ah Kang, MD, Jong Woo Kim, MD, Chul Gu Kim, MD, Tae Gon Lee, MD, Young Ju Lew, MD, Jae Hui Kim, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume56,number1, 39~46쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2015.01.15

영문 초록

Purpose: To evaluate short-term outcomes of intavitreal dexamethasone implant in macular edema secondary to branch retinal vein occlusion (BRVO). Methods: A retrospective review of medical records was performed for 24 patients (24 eyes) who were diagnosed with macular edema secondary to BRVO. The best-corrected visual acuity (BCVA) and central foveal thickness (CFT) were measured before the injection and at 1 and 3 months after the injection. The values measured before and after the treatment were compared. In addition, the association between duration of symptoms and 3-month changes in BCVA was evaluated. Results: In 24 eyes, the logarithm of minimal angle of resolution BCVA before the injection and 1 and 3 months after the injection was 0.56 ± 0.25, 0.42 ± 0.26 and 0.45 ± 0.27, respectively. The CFT was 550.2 ± 116.5 μm, 270.3 ± 101.5 μm, and 356.6 ± 173.7 μm, respectively. When compared with the baseline values, the BCVA at 3 months was significantly improved (p = 0.018) and the CFT was significantly decreased (p < 0.001). There was a significant negative association between the duration of symptoms and 3-month changes in BCVA (p = 0.032, r = -0.375). Elevated intraocular pressure was observed in 3 eyes (12.5%). Conclusions: Intravitreal dexamethasone implant was found effective in treating macular edema secondary to BRVO. However, rebound macular edema and deterioration in visual acuity after 1 month suggest further studies with longer follow-ups are necessary. J Korean Ophthalmol Soc 2015;56(1):39-46

키워드

Clinical outcome, Dexamethasone, Ozurdex, Retinal vein occlusion